Peter Parker dies.
Doctor Octopus clones Peter Parker, Puts His Mind Into Clone and becomes Spider-Man.
Peter Parker gets grafted with Doc Ock’s arms.
Peter Parker becomes the male equivalent of Madam Web.
Miles Morales, the “Ultimate" Spider-Man, is found in the 616-universe and becomes Spider-Man.
Peter Parker loses his powers and is lead to Spider-Man 2099, Miguel O’Hara, who is living peacefully in the universe after the events in the final “Exiles" plot.
Peter Parker has his arms and legs cut off, gets Doc Ock arms and then does something.
Peter Parker and Alpha switch bodies.
Peter Parker retires officially, while Alpha becomes Spider-Man to inherit the role.
A really disturbing series of DeviantART images imagining Peter Parker as a limbless body with a tiny penis being jerked off with a piece of pasta by Mary Jane while Luke Cage apparently has his way with her. Seriously, where the hell did that one come from?